In Drosophila and humans, there are accumulating examples of loci with a significant excess
of high-frequency-derived alleles or high levels of linkage disequilibrium, relative to a …

In this review, we describe recent empirical and theoretical work on the extent of linkage
disequilibrium (LD) in the human genome, comparing the predictions of simple population-…

Abstract Language is a uniquely human trait likely to have been a prerequisite for the
development of human culture. The ability to develop articulate speech relies on capabilities, such …

Understanding why some species have more genetic diversity than others is central to the
study of ecology and evolution, and carries potentially important implications for conservation …

Efforts to identify the genetic basis of human adaptations from polymorphism data have sought
footprints of “classic selective sweeps” (in which a beneficial mutation arises and rapidly …

Meiotic recombination events cluster into narrow segments of the genome, defined as
hotspots. Here, we demonstrate that a major player for hotspot specification is the Prdm9 gene. …

Olfactory receptor (OR) genes constitute the molecular basis for the sense of smell and are
encoded by the largest gene family in mammalian genomes. Previous studies suggested that …

Recombination plays a crucial role in meiosis, ensuring the proper segregation of
chromosomes. Recent linkage disequilibrium (LD) and sperm-typing studies suggest that …

The beneficial substitution of an allele shapes patterns of genetic variation at linked sites.
Thus, in principle, adaptations can be mapped by looking for the signature of directional …

Over the past four decades, the predominant view of molecular evolution saw little
connection between natural selection and genome evolution, assuming that the functionally …