Human COQ8A (ADCK3) and Saccharomyces cerevisiae Coq8p (collectively COQ8) are UbiB
family proteins essential for mitochondrial coenzyme Q (CoQ) biosynthesis. However, the …

The genetics of individual lipid species and their relevance in disease is largely unresolved.
We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across …

The genetic regulation and physiological impact of most lipid species are unexplored. Here,
we profiled 129 plasma lipid species across 49 strains of the BXD mouse genetic reference …

The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic
barriers in lipid biology. In eukaryotes, CoQ precursors—among nature's most hydrophobic …

A mass spectrometry (MS) method is described here that can reproducibly identify hundreds
of peptides across multiple experiments. The method uses intelligent data acquisition to …

Deficiency of the serine hydrolase prolyl endopeptidase-like (PREPL) causes a recessive
metabolic disorder characterized by neonatal hypotonia, feeding difficulties, and growth …

Human COQ8A (ADCK3) and Saccharomyces cerevisiae Coq8p (collectively COQ8) are UbiB
family proteins essential for mitochondrial coenzyme Q (CoQ) biosynthesis. However, the …

In western US states, billions of liters of oil and gas wastewater are discharged to frequently
dry, ephemeral stream beds for bene cial reuse. Elevated sediment radium accumulations …

Lipids are important for a vast array of cellular functions including energy storage and transport,
membrane structure, protein binding, and cell signaling. Due to the overlap of pathways …

Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to
promote bone formation in fracture nonunions, large bone defects, and spinal fusion. However, …