10.7554/eLife.07091.001 Wnt signaling is essential for tissue homeostasis and its
dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), …

Signals propagated by receptor tyrosine kinases (RTKs) can drive cell migration and
proliferation, two cellular processes that do not occur simultaneously—a phenomenon called “…

Cancers represent complex autonomous systems, displaying self‐sufficiency in growth
signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” growth …

Nutrient availability is a key determinant of tumor cell behavior. While nutrient‐rich conditions
favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, …

Simple Summary The kynurenine pathway has two main physiological roles: (i) it protects
specific organs such as the eyes and placenta from strong immune reactions and (ii) it …

10.7554/eLife.20795.001 Loss of epithelial polarity impacts organ development and function;
it is also oncogenic. AMPK, a key sensor of metabolic stress stabilizes cell-cell junctions …

A long-standing issue in the field of signal transduction is to understand the cross-talk between
receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct …

Canonical signal transduction via heterotrimeric G proteins is spatially and temporally restricted,
that is, triggered exclusively at the plasma membrane (PM), only by agonist activation of …

Environmental cues are transmitted to the interior of the cell via a complex network of
signaling hubs. Receptor tyrosine kinases (RTKs) and trimeric G proteins are two such major …

The molecular mechanisms by which receptor tyrosine kinases (RTKs) and heterotrimeric G
proteins, two major signaling hubs in eukaryotes, independently relay signals across the …