The existence of circulating microRNAs (miRNAs) in the blood of cancer patients has raised
the possibility that miRNAs may serve as a novel diagnostic marker. However, the secretory …

In the past several years, the importance of microRNA (miRNA) in cancer cells has been
recognized. Proper control of miRNA expression is essential for maintaining a steady state of …

The release of humoral factors between cancer cells and the microenvironmental cells is
critical for metastasis; however, the roles of secreted miRNAs in non-cell autonomous cancer …

Breast cancer patients often develop metastatic disease years after resection of the primary
tumor. The patients are asymptomatic because the disseminated cells appear to become …

Brain metastasis is an important cause of mortality in breast cancer patients. A key event
during brain metastasis is the migration of cancer cells through blood–brain barrier (BBB). …

Background Breast milk is a complex liquid that provides nutrition to the infant and facilitates
the maturation of the infant's immune system. Recent studies indicated that microRNA (…

Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ) in
the brain because of an imbalance between Aβ production and clearance. Neprilysin (NEP) …

Cancer cells secrete small membranous extracellular vesicles (EVs) into their microenvironment
and circulation. Although their potential as cancer biomarkers has been promising, the …

Recent reports have linked the expression of specific microRNAs (miRNAs) with tumorigenesis
and metastasis. Here, we show that microRNA (miR)-16, which is expressed at lower …

Extracellular vesicles ( EV s), membrane vesicles that are secreted by a variety of mammalian
cell types, have been shown to play an important role in intercellular communication. The …