The heterogeneity of exosomal populations has hindered our understanding of their biogenesis,
molecular composition, biodistribution and functions. By employing asymmetric flow field…

Inhibition of angiogenesis is an important new modality for cancer treatment. 2-methoxyestradiol
(2ME2) is a novel antitumor and antiangiogenic agent, currently in clinical trials, whose …

Acquired resistance to paclitaxel can be mediated by P-glycoprotein or by alterations
involving tubulin. We report two paclitaxel-resistant sublines derived from 1A9 human ovarian …

Epothilones A and B, natural products with minimal structural analogy to taxoids, have effects
similar to those of paclitaxel (Taxol®) in cultured cells and on microtubule protein, but differ …

Chemical compounds that interfere with microtubules such as the vinca alkaloids and taxanes
are important chemotherapeutic agents for the treatment of cancer. As our knowledge of …

The epothilones are naturally occurring antimitotic drugs that share with the taxanes a similar
mechanism of action without apparent structural similarity. Although photoaffinity labeling …

Prostate cancer progression requires active androgen receptor (AR) signaling which occurs
following translocation of AR from the cytoplasm to the nucleus. Chemotherapy with taxanes …

The essential cellular functions associated with microtubules have led to a wide use of
microtubule-interfering agents in cancer chemotherapy with promising results. Although the most …

Here we show that p53 protein is physically associated with tubulin in vivo and in vitro, and
that it localizes to cellular microtubules. Treatment with vincristine or paclitaxel before DNA-…

Geometrically enhanced differential immunocapture (GEDI) and an antibody for prostate-specific
membrane antigen (PSMA) are used for high-efficiency and high-purity capture of …