[HTML][HTML] Nuclear organization in stress and aging

…, PC Ruiz, M Artal-Sanz, P Askjaer, A Dobrzynska - Cells, 2019 - mdpi.com
The eukaryotic nucleus controls most cellular processes. It is isolated from the cytoplasm by
the nuclear envelope, which plays a prominent role in the structural organization of the cell, …

An Efficient FLP-Based Toolkit for Spatiotemporal Control of Gene Expression in Caenorhabditis elegans

…, C Ayuso, A Dobrzynska, A Torres-Mendéz, PC Ruiz… - Genetics, 2017 - academic.oup.com
Site-specific recombinases are potent tools to regulate gene expression. In particular, the Cre
(cyclization recombination) and FLP (flipase) enzymes are widely used to either activate or …

Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR

P de la CruzRuiz, B Hernando‐Rodríguez… - Aging …, 2021 - Wiley Online Library
Mitochondrial prohibitins (PHB) are highly conserved proteins with a peculiar effect on lifespan.
While PHB depletion shortens lifespan of wild‐type animals, it enhances longevity of a …

Analysis of Nuclear Pore Complexes in Caenorhabditis elegans by Live Imaging and Functional Genomics

P de la Cruz Ruiz, R Romero-Bueno… - The Nuclear Pore Complex …, 2022 - Springer
Nuclear pore complexes (NPCs) are essential to communication of macromolecules between
the cell nucleus and the surrounding cytoplasm. RNA RNA synthesized in the nucleus is …

Tissue-specific chromatin-binding patterns of Caenorhabditis elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene …

P de la Cruz-Ruiz, MJ Rodríguez-Palero, P Askjaer… - Genetics, 2023 - academic.oup.com
Heterochromatin is characterized by an enrichment of repetitive elements and low gene
density and is often maintained in a repressed state across cell division and differentiation. The …

NLRP3 inflammasome inhibition by MCC950 in aged mice improves health via enhanced autophagy and PPARα activity

…, MA Cooper, P de la Cruz… - … : Series A, 2020 - academic.oup.com
The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders
and age-related diseases in NLRP3-deficient mice. In this article, we determine whether, in …

[HTML][HTML] Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer

…, A Miranda-Vizuete, A Martínez-Ruiz… - Redox Biology, 2020 - Elsevier
Hepatocellular carcinoma (HCC) represents 80% of the primary hepatic neoplasms. It is the
sixth most frequent neoplasm, the fourth cause of cancer-related death, and 7% of registered …

[HTML][HTML] Quantification and Characterization of CTCs and Clusters in Pancreatic Cancer by Means of the Hough Transform Algorithm

…, C Cepeda-Franco, P de la Cruz-Ojeda… - International Journal of …, 2023 - mdpi.com
Circulating Tumor Cells (CTCs) are considered a prognostic marker in pancreatic cancer. In
this study we present a new approach for counting CTCs and CTC clusters in patients with …

Food addiction and nutritional status in adolescents of a public high school in Mexico

…, JMS Flores, PG de la Cruz… - Enfermeria …, 2020 - investigadores.unison.mx
© Servicio de Publicaciones-Universidad de Murcia. Objective: To know the prevalence of
food addiction according to age, sex, and body mass index and to determine the association …

[HTML][HTML] miR-200c-3p, miR-222-5p, and miR-512-3p constitute a biomarker signature of sorafenib effectiveness in advanced hepatocellular carcinoma

P de la Cruz-Ojeda, T Schmid, L Boix, M Moreno… - Cells, 2022 - mdpi.com
… P de la CO was supported by a FPU predoctoral fellowship (FPU17/00026) from the Ministerio
de Educación, Cultura y Deporte, GEIVEX Mobility Fellowships 2020 and FPU estancias …