There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with
the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using …

The Wnt and Notch signalling pathways represent two major channels of communication used
by animal cells to control their identities and behaviour during development. A number of …

The assignation of cell fates during eukaryotic development relies on the coordinated and
stable expression of cohorts of genes within cell populations. The precise and reproducible …

Abstract Knowledge of the subcellular distribution of proteins is vital for understanding
cellular mechanisms. Capturing the subcellular proteome in a single experiment has proven …

The establishment of the anteroposterior (AP) axis is a crucial step during animal embryo
development. In mammals, genetic studies have shown that this process relies on signals …

Members of the Notch family of receptors act as membrane-tethered transcription factors that
are tightly associated with binary cell fate decisions. Notch signaling acts as a molecular …

Notch is a receptor that mediates intercellular signaling through a pathway conserved across
the metazoa. It is involved in cell fate assignation and pattern formation during development…

The development of the central nervous system is known to result from two sequential
events. First, an inductive event of the mesoderm on the overlying ectoderm that generates a …

The maintenance of pluripotency in mouse embryonic stem cells (mESCs) relies on the
activity of a transcriptional network that is fuelled by the activity of three transcription factors (…

Embryonic Stem cells derived from the epiblast tissue of the mammalian blastocyst retain
the capability to differentiate into any adult cell type and are able to self-renew indefinitely …