Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
D Trachootham, J Alexandre, P Huang - Nature reviews Drug discovery, 2009 - nature.com
Increased generation of reactive oxygen species (ROS) and an altered redox status have
long been observed in cancer cells, and recent studies suggest that this biochemical property …
long been observed in cancer cells, and recent studies suggest that this biochemical property …
[HTML][HTML] The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here
that mice deficient in the mPer2 gene are cancer prone. After γ radiation, these mice show a …
that mice deficient in the mPer2 gene are cancer prone. After γ radiation, these mice show a …
Glucose oxidase‐instructed multimodal synergistic cancer therapy
Over the past 3 years, glucose oxidase (GOx) has aroused great research interest in the
context of cancer treatment due to its inherent biocompatibility and biodegradability, and its …
context of cancer treatment due to its inherent biocompatibility and biodegradability, and its …
Conquering the hypoxia limitation for photodynamic therapy
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to
its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, …
its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, …
ROS stress in cancer cells and therapeutic implications
H Pelicano, D Carney, P Huang - Drug resistance updates, 2004 - Elsevier
Reactive oxygen species (ROS) are constantly generated and eliminated in the biological
system, and play important roles in a variety of normal biochemical functions and abnormal …
system, and play important roles in a variety of normal biochemical functions and abnormal …
Superoxide dismutase as a target for the selective killing of cancer cells
P Huang, L Feng, EA Oldham, MJ Keating, W Plunkett - Nature, 2000 - nature.com
Superoxide dismutases (SOD) are essential enzymes that eliminate superoxide radical (O 2
- ) and thus protect cells from damage induced by free radicals 1 , 2 , 3 . The active O 2 - …
- ) and thus protect cells from damage induced by free radicals 1 , 2 , 3 . The active O 2 - …
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
…, CM Croce, W Plunkett, MJ Keating, P Huang - Nature cell …, 2012 - nature.com
Tissue stromal cells interact with leukaemia cells and profoundly affect their viability and drug
sensitivity. Here we show a biochemical mechanism by which bone marrow stromal cells …
sensitivity. Here we show a biochemical mechanism by which bone marrow stromal cells …
Epigenetic therapy inhibits metastases by disrupting premetastatic niches
Cancer recurrence after surgery remains an unresolved clinical problem 1 , 2 – 3 . Myeloid
cells derived from bone marrow contribute to the formation of the premetastatic …
cells derived from bone marrow contribute to the formation of the premetastatic …
Redox regulation of cell survival
…, MA Ogasawara, NRD Valle, P Huang - Antioxidants & redox …, 2008 - liebertpub.com
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in
regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals …
regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals …
Nanotechnology for multimodal synergistic cancer therapy
The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …