Presynaptic α2δ-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions

PT Kurshan, A Oztan, TL Schwarz - Nature neuroscience, 2009 - nature.com
Synaptogenesis involves the transformation of a growth cone into synaptic boutons specialized
for transmitter release. In Drosophila embryos lacking the α 2 δ-3 subunit of presynaptic, …

Prevalent presence of periodic actin–spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

…, Z Wu, MA Carrasco, PT Kurshan… - Proceedings of the …, 2016 - National Acad Sciences
Actin, spectrin, and associated molecules form a periodic, submembrane cytoskeleton in the
axons of neurons. For a better understanding of this membrane-associated periodic …

A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport

E Pack-Chung, PT Kurshan, DK Dickman… - Nature …, 2007 - nature.com
The morphological transition of growth cones to synaptic boutons characterizes synaptogenesis.
Here we have isolated mutations in immaculate connections (imac; CG8566), a …

Synaptogenic pathways

PT Kurshan, K Shen - Current opinion in neurobiology, 2019 - Elsevier
… Author links open overlay panel Peri T Kurshan 3 , Kang Shen 1 2 … Enustun, T. Ejikeme,
R.-R. … PT Kurshan, AQ Phan, GJ Wang, MM Crane, H. Lu, K. Shen …

Locomotor activity is regulated by D2‐like receptors in Drosophila: an anatomic and functional analysis

I Draper, PT Kurshan, E McBride… - Developmental …, 2007 - Wiley Online Library
In mammals, dopamine 2-like receptors are expressed in distinct pathways within the central
nervous system, as well as in peripheral tissues. Selected neuronal D2-like receptors play …

Autonomous screening of C. elegans identifies genes implicated in synaptogenesis

MM Crane, JN Stirman, CY Ou, PT Kurshan, JM Rehg… - Nature …, 2012 - nature.com
Morphometric studies in multicellular organisms are generally performed manually because
of the complexity of multidimensional features and lack of appropriate tools for handling …

Characterization of a D2-like dopamine receptor (AmDOP3) in honey bee, Apis mellifera

KT Beggs, IS Hamilton, PT Kurshan, JA Mustard… - Insect biochemistry and …, 2005 - Elsevier
Dopamine is an important neurotransmitter in vertebrate and invertebrate nervous systems
and is widely distributed in the brain of the honey bee, Apis mellifera. We report here the …

Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release

…, JE Richmond, DA Colon-Ramos, K Shen, PT Kurshan - Elife, 2017 - elifesciences.org
10.7554/eLife.29276.001 Active zone proteins cluster synaptic vesicles at presynaptic
terminals and coordinate their release. In forward genetic screens, we isolated a novel …

Mutations in a Drosophila α2δ voltage-gated calcium channel subunit reveal a crucial synaptic function

DK Dickman, PT Kurshan, TL Schwarz - Journal of Neuroscience, 2008 - Soc Neuroscience
Voltage-dependent calcium channels regulate many aspects of neuronal biology, including
synaptic transmission. In addition to their α 1 subunit, which encodes the essential voltage …

[PDF][PDF] γ-Neurexin and frizzled mediate parallel synapse assembly pathways antagonized by receptor endocytosis

PT Kurshan, SA Merrill, Y Dong, C Ding… - Neuron, 2018 - cell.com
Synapse formation defines neuronal connectivity and is thus essential for neuronal circuit
assembly. Trans-synaptic interactions of cell adhesion molecules are thought to induce …