To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied
single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling …

Microsystems create new opportunities for the spatial and temporal control of cell growth
and stimuli by combining surfaces that mimic complex biochemistries and geometries of the …

An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global …

In microorganisms, noise in gene expression gives rise to cell-to-cell variability in protein
concentrations 1 , 2 , 3 , 4 , 5 , 6 , 7 . In mammalian cells, protein levels also vary 8 , 9 , 10 and …

Immune checkpoint inhibitors (ICIs) produce durable responses in some melanoma patients,
but many patients derive no clinical benefit, and the molecular underpinnings of such …

Heat shock promoters contain one or more binding sites for a specific heat shock factor (HSF).
We report the cloning and sequence of the gene encoding yeast HSF, and demonstrate …

The mitotic checkpoint protein hsMad2 is required to arrest cells in mitosis when chromosomes
are unattached to the mitotic spindle 1 . The presence of a single, lagging chromosome is …

AlphaFold2 and related computational systems predict protein structure using deep
learning and co-evolutionary relationships encoded in multiple sequence alignments (MSAs). …

Obesity is a major cancer risk factor, but how differences in systemic metabolism change the
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …

Crosstalk and complexity within signaling pathways and their perturbation by oncogenes
limit component-by-component approaches to understanding human disease. Network …