[HTML][HTML] Observational Health Data Sciences and Informatics (OHDSI): opportunities for observational researchers
The vision of creating accessible, reliable clinical evidence by accessing the clinical
experience of hundreds of millions of patients across the globe is a reality. The Observational …
experience of hundreds of millions of patients across the globe is a reality. The Observational …
[HTML][HTML] Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study
Background Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid
arthritis, has received much negative publicity for adverse events associated with its …
arthritis, has received much negative publicity for adverse events associated with its …
Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults
…, D Ansell, A Pasqua, F Lapi, P Rijnbeek… - bmj, 2019 - bmj.com
Objective To estimate the risk of acute myocardial infarction (AMI) or stroke in adults with
non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH). Design …
non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH). Design …
Design and implementation of a standardized framework to generate and evaluate patient-level prediction models using observational healthcare data
…, MA Suchard, PB Ryan, PR Rijnbeek - Journal of the …, 2018 - academic.oup.com
Objective To develop a conceptual prediction model framework containing standardized
steps and describe the corresponding open-source software developed to consistently …
steps and describe the corresponding open-source software developed to consistently …
[HTML][HTML] The role of explainability in creating trustworthy artificial intelligence for health care: a comprehensive survey of the terminology, design choices, and …
Artificial intelligence (AI) has huge potential to improve the health and well-being of people,
but adoption in clinical practice is still limited. Lack of transparency is identified as one of the …
but adoption in clinical practice is still limited. Lack of transparency is identified as one of the …
Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: multinational network cohort study
…, A Delmestri, K Verhamme, PR Rijnbeek… - bmj, 2021 - bmj.com
Objective To quantify the background incidence rates of 15 prespecified adverse events of
special interest (AESIs) associated with covid-19 vaccines. Design Multinational network …
special interest (AESIs) associated with covid-19 vaccines. Design Multinational network …
[HTML][HTML] Real-world data reveal a diagnostic gap in non-alcoholic fatty liver disease
…, D Ansell, A Pasqua, F Lapi, P Rijnbeek… - BMC medicine, 2018 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver
disease worldwide. It affects an estimated 20% of the general population, based on cohort …
disease worldwide. It affects an estimated 20% of the general population, based on cohort …
[HTML][HTML] Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in …
…, D Ansell, A Pasqua, F Lapi, P Rijnbeek… - BMC medicine, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a common condition that progresses
in some patients to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). …
in some patients to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). …
[HTML][HTML] Prediction of RNA-protein sequence and structure binding preferences using deep convolutional and recurrent neural networks
Background RNA regulation is significantly dependent on its binding protein partner, known
as the RNA-binding proteins (RBPs). Unfortunately, the binding preferences for most RBPs …
as the RNA-binding proteins (RBPs). Unfortunately, the binding preferences for most RBPs …
[HTML][HTML] Renin–angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis
…, AG Sena, MJ Schuemie, PR Rijnbeek… - The Lancet Digital …, 2021 - thelancet.com
Background Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor
blockers (ARBs) have been postulated to affect susceptibility to COVID-19. Observational …
blockers (ARBs) have been postulated to affect susceptibility to COVID-19. Observational …