Recent advances in multi-electrode array technology have made it possible to monitor large
neuronal ensembles at cellular resolution in animal models. In humans, however, current …

G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors
transmitting extracellular signals into cells. Here we show that central components of a …

Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Despite improving rates of survival after traumatic brain injury (TBI), many head-injured
patients incur permanent neurologic impairment. Each year in the United States, approximately …

Humans’ ability to rapidly and accurately detect, identify and classify faces under variable
conditions derives from a network of brain regions highly tuned to face information. The …

Ketamine produces antidepressant effects in patients with treatment-resistant depression,
but its usefulness is limited by its psychotropic side effects. Ketamine is thought to act via …

BACKGROUND: Deep brain stimulation electrode placement with interventional magnetic
resonance imaging (MRI) has previously been reported using a commercially available skull-…

Gene therapy has the potential to provide therapeutic benefit to millions of people with
neurodegenerative diseases through several means, including direct correction of pathogenic …

Clinical trials involving direct infusion of neurotrophic therapies for Parkinson's disease (PD)
have suffered from poor coverage of the putamen. The planned use of a novel interventional…

Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high-…