Cdc42 – a member of the small Rho GTPase family – regulates cell polarity across organisms
from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial …

Steroid hormone receptors act to regulate specific gene transcription primarily as steroid-specific
dimers bound to palindromic DNA response elements. DNA-dependent dimerization …

Background In Drosophila epithelial cells, specification and maintenance of the zonula
adherens (za) is crucial to ensure epithelial tissue integrity. This depends on the intertwined …

Cell constriction promotes epithelial sheet invagination during embryogenesis across phyla.
However, how this cell response is linked to global patterning information during …

The mineralocorticoid receptor (MR) is a tightly regulated nuclear hormone receptor that
selectively transmits corticosteroid signals. Steroid treatment transforms MR from a …

Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC),
Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work …

The glucocorticoid receptor (GR) cycles between a naive chaperone-complexed form in the
cytoplasm and a transcriptionally active steroid-bound nuclear form. Nuclear import of GR …

Movement of epithelial cells in a tissue occurs through neighbor exchange and drives tissue
shape changes. It requires intercellular junction remodeling, a process typically powered by …

This immunofluorescence protocol can be used to assay cell morphology, cell positioning
and subcellular localization of proteins in the fly eye at stages of development from early …

Nucleocytoplasmic exchange of nuclear hormone receptors is hypothesized to allow for rapid
and direct interactions with cytoplasmic signaling factors. In addition to recycling between …