The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …

Most cancer cells harbor multiple drivers whose epistasis and interactions with expression
context clouds drug and drug combination sensitivity prediction. We constructed a …

Abnormalities of striatal glutamate neurotransmission may play a role in the pathophysiology
of Parkinson's disease and may respond to neurosurgical interventions, specifically …

Parkinson's disease (PD) is one of the most common movement disorders, and currently there
is no effective treatment that can slow disease progression. Preserving and enhancing DA …

Fluorescence-based western blots are quantitative in principal, but require determining
linear range for each antibody. Here, we use microwestern array to rapidly evaluate suitable …

Interferon regulatory factor-1 (IRF-1) is a member of a family of transcription factors that regulate
an array of genes involved in cell growth, differentiation, and death. Analysis of cytokine …

It is not known how neurosurgical interventions benefit patients with Parkinson's disease.
We compared the effects of electrical stimulation and electrolytic lesions of the subthalamic …

We have analyzed interleukin (IL)-6 gene transcription and IL-6 secretion by murine B cells
in vitro. Mitogenic doses of lipopolysaccharide (LPS) or LPS in combination with F(ab′) 2 …

The mechanism by which deep brain stimulation (DBS) of the subthalamic nucleus (STN)
achieves its effects in Parkinson's disease (PD) is not known. In animal models of PD, …

Abstract Analysis of optimal sites for neurosurgical interventions in patients with Parkinson's
disease (PD) suggests that significant clinical benefits may be achieved by involvement of …