Construction of short tandem target mimic (STTM) to block the functions of plant and animal microRNAs

G Tang, J Yan, Y Gu, M Qiao, R Fan, Y Mao, X Tang - Methods, 2012 - Elsevier
Small RNAs are widespread in plants and animals. They largely include microRNAs (miRNAs)
and short interfering RNAs (siRNAs), and they play key roles in gene and chromatin …

[PDF][PDF] Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice

…, Y Bi, H Chen, WJ Liu, J Qi, Q Cui, S Qi, R Fan… - Cell Reports …, 2023 - cell.com
With the widespread vaccinations against coronavirus disease 2019 (COVID-19), we are
witnessing gradually waning neutralizing antibodies and increasing cases of breakthrough …

Coat color determination by miR-137 mediated down-regulation of microphthalmia-associated transcription factor in a mouse model

C Dong, H Wang, L Xue, Y Dong, L Yang, R Fan, X Yu… - Rna, 2012 - rnajournal.cshlp.org
Coat color is a key economic trait in wool-producing species. Color development and
pigmentation are controlled by complex mechanisms in animals. Here, we report the first …

A novel nanobody targeting Middle East respiratory syndrome coronavirus (MERS-CoV) receptor-binding domain has potent cross-neutralizing activity and protective …

…, Y Chen, Y Guo, Y Wang, J Shang, K Ji, R Fan… - Journal of …, 2018 - Am Soc Microbiol
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) continues
to infect humans and camels, calling for efficient, cost-effective, and broad-spectrum …

[PDF][PDF] An updated view of leptin on implantation and pregnancy: a review

M Herrid, SKA Palanisamy, UA Ciller, R Fan… - Physiological …, 2014 - researchgate.net
The hormone leptin, which is thought to be primarily produced by adipose tissue, is a
polypeptide that was initially characterized by its ability to regulate food intake and energy …

[HTML][HTML] Skin transcriptome profiles associated with coat color in sheep

R Fan, J Xie, J Bai, H Wang, X Tian, R Bai, X Jia… - BMC genomics, 2013 - Springer
Background Previous molecular genetic studies of physiology and pigmentation of sheep
skin have focused primarily on a limited number of genes and proteins. To identify additional …

[HTML][HTML] Genomic analysis of the domestication and post-Spanish conquest evolution of the llama and alpaca

R Fan, Z Gu, X Guang, JC Marín, V Varas, BA González… - Genome biology, 2020 - Springer
Background Despite their regional economic importance and being increasingly reared
globally, the origins and evolution of the llama and alpaca remain poorly understood. Here we …

[HTML][HTML] MicroRNA-21a-5p functions on the regulation of melanogenesis by targeting Sox5 in mouse skin melanocytes

P Wang, Y Zhao, R Fan, T Chen, C Dong - International Journal of …, 2016 - mdpi.com
MicroRNAs (miRNAs) play an important role in regulating almost all biological processes.
miRNAs bind to the 3′ untranslated region (UTR) of mRNAs by sequence matching. In a …

[HTML][HTML] Identification and characterization of microRNAs in white and brown alpaca skin

X Tian, J Jiang, R Fan, H Wang, X Meng, X He, J He… - BMC genomics, 2012 - Springer
Background MicroRNAs (miRNAs) are small, non-coding 21–25 nt RNA molecules that play
an important role in regulating gene expression. Little is known about the expression …

[HTML][HTML] MicroRNA-27a-3p inhibits melanogenesis in mouse skin melanocytes by targeting Wnt3a

…, P Wang, J Meng, Y Ji, D Xu, T Chen, R Fan… - International journal of …, 2015 - mdpi.com
MicroRNAs (miRNAs) play an essential role in the regulation of almost all the biological
processes, including melanogenesis. MiR-27a-3p is nearly six times higher in white alpaca skin …