User profiles for S Sigurbjörnsdóttir

Sara Sigurbjörnsdóttir

Assistant professor at the University of Iceland, Faculty of Life and environmental sciences
Verified email at hi.is
Cited by 733

Molecular mechanisms of de novo lumen formation

S Sigurbjörnsdóttir, R Mathew, M Leptin - Nature reviews Molecular cell …, 2014 - nature.com
Many organs contain networks of epithelial tubes that transport gases or fluids. A lumen can
be generated by tissue that enwraps a pre-existing extracellular space or it can arise de …

Hedgehog signalling in bone and osteoarthritis: the role of Smoothened and cholesterol

…, E Steingrimsson, S Sigurbjörnsdóttir - The FEBS …, 2023 - Wiley Online Library
… acid residues of the CRD cholesterol-binding pocket (Leu108, Trp109, Pro164, Phe166,
Asp95 and Tyr130) are known to inhibit binding of cholesterol or 20-hydroxycholesterol (20(S)-…

[HTML][HTML] A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2

…, S Sigurbjörnsdóttir, J Steinmann, S Sudarsan… - BMC systems …, 2011 - Springer
… in S. Typhimurium biology and systems biology collaborated to reconcile and expand the
S. … The consensus MR was obtained starting from two independently developed MRs for S. …

Validity of self-report and informant rating scales of adult ADHD symptoms in comparison with a semistructured diagnostic interview

…, S Hreiðarsson, S Sigurbjörnsdóttir… - Journal of Attention …, 2006 - journals.sagepub.com
… In the first telephone contact with the participants they were encouraged to inquire among
the proband’s first-, second-, and third-degree relatives who would be willing to participate in …

Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology

LD Rios-Barrera, S Sigurbjörnsdóttir… - Proceedings of the …, 2017 - National Acad Sciences
Tango1 enables ER-to-Golgi trafficking of large proteins. We show here that loss of Tango1,
in addition to disrupting protein secretion and ER/Golgi morphology, causes ER stress and …

Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis

…, K Bjarnadottir, S Sigurbjornsdottir, S Jonsson… - Nature …, 2018 - nature.com
Osteoarthritis has a highly negative impact on quality of life because of the associated pain
and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis of …

[HTML][HTML] MITF has a central role in regulating starvation-induced autophagy in melanoma

K Möller, S Sigurbjornsdottir, AO Arnthorsson… - Scientific reports, 2019 - nature.com
… All procedures were performed according to manufacturer’s instructions. Primers were
designed for each target gene using NCBI Primer BLAST (Sup. Table 5), and qRT-PCR was …

MITF reprograms the extracellular matrix and focal adhesion in melanoma

…, OM Eichhoff, P Cerny, K Möller, S Sigurbjörnsdóttir… - Elife, 2021 - elifesciences.org
… The online version of this article includes the following source data and figure supplement(s
The online version of this article includes the following source data and figure supplement(s) …

A genome-wide screen for dendritically localized RNAs identifies genes required for dendrite morphogenesis

…, I Barlow, S Sigurbjornsdottir… - G3: Genes, genomes …, 2016 - academic.oup.com
… Statistical significance was determined by Student’s t-test. Note that images shown in Figure
1 were cropped and adjusted … Statistical significance was determined using Student’s t-test. …

[HTML][HTML] Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen

HN Vu, MM Valdimarsson, S Sigurbjörnsdóttir… - bioRxiv, 2023 - ncbi.nlm.nih.gov
… reagent (ThermoFisher, #15596–026) High-Capacity cDNA Reverse Transcription Kit (Applied
Biosystems, #4368814) was used for cDNA synthesis according to the manufacturer’s