Accurate annotation of genes and their transcripts is a foundation of genomics, but currently
no annotation technique combines throughput and accuracy. As a result, reference gene …

The interplay of active and repressive histone modifications is assumed to have a key role in
the regulation of gene expression. In contrast to this generally accepted view, we show that …

Tissue function and homeostasis reflect the gene expression signature by which the combination
of ubiquitous and tissue-specific genes contribute to the tissue maintenance and stimuli…

An important mechanism for gene regulation involves chromatin changes via histone
modification. One such modification is histone H3 lysine 4 trimethylation (H3K4me3), which …

The homeotic Abdominal-B ( Abd-B ) gene expression depends on a modular cis -regulatory
region divided into discrete functional domains ( iab ) that control the expression of the …

CRISPR-Cas9 screening libraries have arisen as a powerful tool to identify protein-coding (pc)
and non-coding genes playing a role along different processes. In particular, the usage of …

H3K4me3 is a histone modification that accumulates at the transcription-start site (TSS) of
active genes and is known to be important for transcription activation. The way in which …

Natural Antisense Transcripts (NATs) are long non-coding RNAs (lncRNAs) that overlap
coding genes in the opposite strand. NATs roles have been related to gene regulation through …

Background The trithorax group (trxG) and Polycomb group (PcG) proteins are responsible
for the maintenance of stable transcriptional patterns of many developmental regulators. …

Gene expression is regulated by proteins such as transcription factors, as well as by chromatin
modifications on DNA and histones. Some histone modifications have been associated to …