Epidemiological studies have established that many tumours occur in association with
persistent inflammation. One clear example of inflammation-related cancer is hepatocellular …

Cancer is a complex disease involving alterations of multiple processes, with both genetic
and epigenetic features contributing as core factors to the disease. In recent years, it has …

Hepatocarcinogenesis is a complex multistep process in which many different molecular
pathways have been implicated. Hepatocellular carcinoma (HCC) is refractory to conventional …

The identification of molecular mechanisms involved in the maintenance of the transformed
phenotype of hepatocellular carcinoma (HCC) cells is essential for the elucidation of …

Humans with obesity differ in their susceptibility to developing insulin resistance and type 2
diabetes (T2D). This variation may relate to the extent of adipose tissue (AT) inflammation …

The Wilms' tumor 1 gene (WT1) encodes a transcription factor involved in cell growth and
development. As we previously reported, WT1 expression is hardly detectable in normal …

BACKGROUND & AIMS: Inactivation of the product of the tumor suppressor gene TP73 does
not usually occur by mutation but rather through expression of truncated isoforms that have …

A precise equilibrium between cellular differentiation and proliferation is fundamental for
tissue homeostasis. Maintaining this balance is particularly important for the liver, a highly …

The hepatic wound‐healing response to chronic noxious stimuli may lead to liver fibrosis, a
condition characterized by excessive deposition of extracellular matrix. Fibrogenic cells, …

Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation.
How fat-rich diets promote progression from fatty liver to more damaging inflammatory …