Dynamic reorganization of the actin cytoskeleton at the leading edge is required for directed
cell migration. Cofilin, a small actin-binding protein with F-actin severing activities, is a key …

Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches
to control biological processes, and thus there is significant interest within the synthetic …

Sphingolipids are essential components of cellular membranes and defects in their synthesis
or degradation cause severe human diseases. The efficient degradation of sphingolipids in …

Krabbe disease is a devastating neurodegenerative disorder characterized by rapid
demyelination of nerve fibers. This disease is caused by defects in the lysosomal enzyme β-…

Background Protein kinase D (PKD) enzymes regulate cofilin-driven actin reorganization
and directed cell migration through both p21-activated kinase 4 (PAK4) and the phosphatase …

Krabbe disease is a severe, fatal neurodegenerative disorder caused by defects in the lysosomal
enzyme galactocerebrosidase ( GALC ). The correct targeting of GALC to the lysosome …

PAKs (p21-activated kinases) are effectors of RhoGTPases. PAK4 contributes to regulation
of cofilin at the leading edge of migrating cells through activation of LIMK (Lin-11/Isl-1/Mec-3 …

Missense mutations in the lysosomal hydrolase β‐galactocerebrosidase (GALC) account for
at least 40% of known cases of Krabbe disease (KD). Most of these missense mutations are …

Saposins are lipid transfer proteins required for the degradation of sphingolipids in the
lysosome. These small proteins bind lipids by transitioning from a closed, monomeric state to an …

Sphingolipids are essential components of cellular membranes and defects in their synthesis
or degradation cause severe human diseases. The efficient degradation of sphingolipids in …