Rab proteins are best known for their essential roles in exocytic and endocytic membrane
trafficking, which encompass the constitutive and regulated secretory routes, endocytosis via …

Single molecule localization based super-resolution imaging techniques require repeated
localization of many single emitters. We describe a method that uses the maximum likelihood …

Analysis of autoinflammatory and immunodeficiency disorders elucidates human immunity
and fosters the development of targeted therapies. Oligoadenylate synthetase 1 is a type I …

γ9δ2T cells play a major role in cancer immune surveillance, yet the clinical translation of
their in vitro promise remains challenging. To address limitations of previous clinical attempts …

The innate immune system is a broad collection of critical intra‐ and extra‐cellular processes
that limit the infectivity of diverse pathogens. The 2′‐5′‐oligoadenylate synthetase (OAS…

2′-5′-Oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded
RNA (dsRNA) and play a critical role in limiting viral infection. dsRNA binding …

GGGGCC (G4C2) hexanucleotide repeat expansion in the C9ORF72 gene is the most
common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). …

GABAergic synaptic inhibition controls neuronal firing, excitability, and synaptic plasticity to
regulate neuronal circuits. Following an acute excitotoxic insult, inhibitory synapses are …

Long-term potentiation (LTP) of excitatory synapses is a major form of plasticity for learning
and memory in the central nervous system. While the molecular mechanisms of LTP have …

Fc receptors (FcRs) are an important bridge between the innate and adaptive immune
system. Fc gamma receptor I (FcγRI; CD64), the high-affinity receptor for immunoglobulin G (IgG), …