The P2Y 2 receptor, which is activated by UTP, ATP, and dinucleotides, was studied as a
prototypical nucleotide-activated GPCR. A combination of receptor mutagenesis, determination …

The CDK4/6 inhibitor palbociclib blocks cell cycle progression in Estrogen receptor–positive,
human epidermal growth factor 2 receptor–negative (ER+/HER2−) breast tumor cells. …

It is well known that clonal cells can make different fate decisions, but it is unclear whether
these decisions are determined during, or before, a cell's own lifetime. Here, we engineered …

Single-cell technologies can measure the expression of thousands of molecular features in
individual cells undergoing dynamic biological processes. While examining cells along a …

Two size forms of ADAR1 adenosine deaminase are known, one constitutively expressed (p110)
and the other interferon (IFN)-induced (p150). To test the role of ADAR1 in viral infection…

The RNA-specific adenosine deaminase (ADAR1) is an interferon-inducible editing enzyme
that converts adenosine to inosine. ADAR1 contains three distinct domains: a N-terminal Z-…

Eight human G protein-coupled P2Y receptors (P2Y 1 , P2Y 2 , P2Y 4 , P2Y 6 , P2Y 11 , P2Y
12 , P2Y 13 , and P2Y 14 ) that respond to extracellular nucleotides have been molecularly …

The P2Y 1 receptor is localized to the basolateral membrane of polarized Madin-Darby canine
kidney (MDCK) cells. In the present study, we identified a 25-residue region within the C-…

P2Y 2 and P2Y 4 receptors, which have 52% sequence identity, are both expressed at the
apical membrane of Madin-Darby canine kidney cells, but the locations of their apical …

Nucleotide stimulation of G q -coupled P2Y receptors expressed in Xenopus laevis oocytes
produces the activation of an endogenous voltage-gated ion channel, previously identified …