In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203–213], the presence of CD3
+ tumor-infiltrating lymphocytes (TILs) was found to correlate with improved survival in …

Compelling evidence indicates that the CRISPR-Cas system protects prokaryotes from
viruses and other potential genome invaders. This adaptive prokaryotic immune system arises …

Purpose Endometrial cancers have long been divided into estrogen-dependent type I and
the less common clinically aggressive estrogen-independent type II. Little is known about risk …

Circularization was recently recognized to broadly expand transcriptome complexity. Here,
we exploit massive Drosophila total RNA-sequencing data, >5 billion paired-end reads from >…

mRNA degradation represents a critical regulated step in gene expression. Although the
major pathways in turnover have been identified, accounting for disparate half-lives has been …

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer
with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 …

Many proteins regulate the expression of genes by binding to specific regions encoded in the
genome 1. Here we introduce a new data set of RNA elements in the human genome that …

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide
association studies, we observed large chromosomal abnormalities in a subset of clones in …

Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing
an ensemble of transcript isoforms that give rise to substantial diversity. Here we have …

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected
individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and …