10.7554/eLife.23326.001 Upon fertilization, the genome of animal embryos remains
transcriptionally inactive until the maternal-to-zygotic transition. At this time, the embryo takes control …

Ovarian granulosa cells display strong androgen receptor (AR) expression, suggesting a
functional role for direct AR-mediated actions within developing mammalian follicles. By …

After fertilization, the embryonic genome is inactive until transcription is initiated during the
maternal-to-zygotic transition. How the onset of transcription is regulated in a precisely timed …

Homozygous androgen receptor (AR)-knockout (ARKO) female mice are subfertile due to
both intra- and extraovarian (neuroendocrine) defects as defined by ovary transplantation. …

Absolute quantification of proteins elucidates the molecular composition, regulation and
dynamics of multiprotein assemblies and networks. Here we report on a method termed MS …

Forward genetic screens remain at the forefront of biology as an unbiased approach for
discovering and elucidating gene function at the organismal and molecular level. Past …

The advances of split-pool organic synthesis1 and highthroughput biological screens2 have
provided new opportunities for the discovery of man-made molecules with novel biological …

… Shair and coworkers utilized these characteristics in developing a biomimetic synthesis[37] …
from nature, Shair and coworkers [38] developed a novel reaction that would result in inter- …

Cellular tasks such as transcription rely on stochastic interactions of biomolecules. Thus,
single molecule methods are beneficial in revealing the kinetic and structural underpinnings of …

Due to the growing interest in small molecules that could help in understanding protein–protein
interactions based on signal transduction, the demand for the generation of small-…