[PDF][PDF] A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade
Immune checkpoint inhibitors (ICIs) produce durable responses in some melanoma patients,
but many patients derive no clinical benefit, and the molecular underpinnings of such …
but many patients derive no clinical benefit, and the molecular underpinnings of such …
A single-cell landscape of high-grade serous ovarian cancer
Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade
serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor …
serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor …
[HTML][HTML] Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
The architecture of normal and diseased tissues strongly influences the development and
progression of disease as well as responsiveness and resistance to therapy. We describe a …
progression of disease as well as responsiveness and resistance to therapy. We describe a …
[PDF][PDF] A human breast atlas integrating single-cell proteomics and transcriptomics
…, WL Goh, K Moore, HK Shapiro, S Mei… - Developmental cell, 2022 - cell.com
The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables on …
conditions alters its disease susceptibility, yet the specific effects of these clinical variables on …
Evolution of delayed resistance to immunotherapy in a melanoma responder
Despite initial responses 1 , 2 – 3 , most melanoma patients develop resistance 4 to immune
checkpoint blockade (ICB). To understand the evolution of resistance, we studied 37 tumor …
checkpoint blockade (ICB). To understand the evolution of resistance, we studied 37 tumor …
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
…, CC Luo, R Mylvaganam, L Nguyen, S Mei… - Nature medicine, 2021 - nature.com
Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18–SSX fusion, and is
characterized by low T cell infiltration. Here, we studied the cancer–immune interplay in SyS …
characterized by low T cell infiltration. Here, we studied the cancer–immune interplay in SyS …
[HTML][HTML] Exceptional response and multisystem autoimmune-like toxicities associated with the same T cell clone in a patient with uveal melanoma treated with immune …
…, B Izar, C Batenchuk, A Avila, S Mei… - … for immunotherapy of …, 2019 - Springer
Balancing the potential for durable remissions with autoimmune-like toxicities is a key clinical
challenge in the use of immune checkpoint inhibitors (ICI). Certain toxicities are associated …
challenge in the use of immune checkpoint inhibitors (ICI). Certain toxicities are associated …
[HTML][HTML] Response and mechanisms of resistance to larotrectinib and selitrectinib in metastatic undifferentiated sarcoma harboring oncogenic fusion of NTRK1
ML Hemming, MJ Nathenson, JR Lin, S Mei… - JCO precision …, 2020 - ncbi.nlm.nih.gov
Oncogenic translocations involving the neurotrophic receptor tyrosine kinase genes (NTRK1,
NTRK2, and NTRK3), which encode the 3 tropomyosin receptor kinases (TRKs; TRKA, …
NTRK2, and NTRK3), which encode the 3 tropomyosin receptor kinases (TRKs; TRKA, …
Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activity
HASPIN inhibition by CX-6258 is a novel and potent strategy for RAF/MEK inhibitor–resistant
melanoma and potentially other tumor types. HASPIN inhibition has direct antitumor activity …
melanoma and potentially other tumor types. HASPIN inhibition has direct antitumor activity …
The ubiquitin-editing enzyme A20 regulates synapse remodeling and efficacy
Ubiquitination and its reverse process, deubiquitination, play essential roles in neural
development, function, and plasticity. A20, a ubiquitin editing enzyme that can remove K63-…
development, function, and plasticity. A20, a ubiquitin editing enzyme that can remove K63-…