The unique mental abilities of humans are rooted in the immensely expanded and folded
neocortex, which reflects the expansion of neural progenitors, especially basal progenitors …

The primary cilium, a signaling organelle projecting from the surface of a cell, controls cellular
physiology and behavior. The presence or absence of primary cilia is a distinctive feature …

Mechanistic target of rapamycin (MTOR) cooperates with Hedgehog (HH) signaling, but the
underlying mechanisms are incompletely understood. Here we provide genetic, biochemical…

We found that the secreted serine protease xHtrA1, expressed in the early embryo and
transcriptionally activated by FGF signals, promotes posterior development in mRNA-injected …

The neocortex, the center for higher brain function, first emerged in mammals and has
become massively expanded and folded in humans, constituting almost half the volume of the …

Hedgehog (Hh) and Wnt proteins are important signals implicated in several aspects of
embryonic development, including the early development of the central nervous system. We …

The neocortex, the center for higher brain function, emerged in mammals and expanded in
the course of evolution. The expansion of outer radial glia (oRGs) and intermediate …

Secreted proteins play a crucial role in intercellular communication during embryogenesis
and in the adult. We recently described a novel method, designated as secretion cloning, that …

In the version of this article initially published, the Figure 1e, f legend read,“Circulating levels
of LH (left panels) and FSH (right panels) in GnRH cells of control (blue) and Dicer mutants (…

Cell-extrinsic signals and intrinsic cell cycle regulators strictly control proliferation. Cancers
develop from a cell that escapes these tight controls and proliferates unrestrictedly. The …