To date, the crystal structures of at least 12 human CYPs (1A2, 2A6, 2A13, 2C8, 2C9, 2D6,
2E1, 2R1, 3A4, 7A1, 8A1, and 46A1) have been determined. CYP2D6 accounts for only a …

Human cytochrome P450 2C9 (CYP2C9) accounts for ∼20% of total hepatic CYP content
and metabolizes ∼15% clinically used drugs including S-warfarin, tolbutamide, phenytoin, …

The natural polyamine spermidine and spermine have been reported to ameliorate aging
and aging-induced dementia. However, the mechanism is still confused. An aging model, the …

Chondroitin sulfate (CS) has shown either ameliorating or aggravating effects on osteoarthritis
(OA) in separately conducted clinical trials. Because CS is usually administered orally, it …

Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the
alleviation of various neurodegenerative diseases. However, there are few studies about its …

The Chinese formula Bushen-Yizhi (BSYZ) has been reported to ameliorate cognitive
dysfunction. However the mechanism is still unclear. In this study, we employ an aging model, …

Angelica sinensis (AS, Danggui in Chinese) is an important herbal component of various
traditional formulae for the management of asthenia and its tonic effects. Although AS has been …

The abnormal deposition of the extracellular amyloid-β peptide is the typical pathological
hallmark of Alzheimer’s disease. Strategies to reduce the amyloid-β deposition effectively …

… Author links open overlay panel Jian-Hui Xie a 1 , Zhi-Wei Chen b c 1 , Ya-Wei Pan d , De-Min
Luo d , Zi-Ren Su e , Hai-Ming Chen c , Zhen Qin f , Shui-Qing Huang g , Gao Lei d …

Although artemisinin has been used as anti-malarial drug, accumulating evidence on the
extended therapeutic potential of artemisinin emerges. Apart from anti-malaria and anti-tumor, …