PROTEIN-protein interactions between two proteins have generally been studied using
biochemical techniques such as crosslinking, co-immunoprecipitation and co-fractionation by …

Two large-scale yeast two-hybrid screens were undertaken to identify protein–protein
interactions between full-length open reading frames predicted from the Saccharomyces …

Comprehensive protein–protein interaction maps promise to reveal many aspects of the
complex regulatory network underlying cellular function. Recently, large-scale approaches have …

A global analysis of 2,709 published interactions between proteins of the yeast Saccharomyces
cerevisiae has been performed, enabling the establishment of a single large network of …

The p53 gene is frequently mutated in a wide variety of human cancers. However, the role of
the wild-type p53 gene in growth control is not known. Hybrid proteins that contain the DNA …

Layered on top of information conveyed by DNA sequence and chromatin are higher order
structures that encompass portions of chromosomes, entire chromosomes, and even whole …

Interactions between proteins mediate most biological processes, and a variety of biochemical
procedures has been developed for their assay. The two-hybnd system exploits the ability …

Mutagenesis provides insight into proteins, but only recently have assays that couple genotype
to phenotype been used to assess the activities of as many as 1 million mutant versions …

The long-term challenge of proteomics is enormous: to define the identities, quantities,
structures and functions of complete complements of proteins, and to characterize how these …

If the architect you hired to design your home brought you a blueprint that solely consisted of
a long list of parts that began “windowwabeborogovestaircasedoorjubjub…,” you might start …