Background Results of small trials indicate that fluoxetine might improve functional outcomes
after stroke. The FOCUS trial aimed to provide a precise estimate of these effects. Methods …

Clathrin-mediated endocytosis (CME) is vital for the internalization of most cell-surface proteins.
In CME, plasma membrane–binding clathrin adaptors recruit and polymerize clathrin to …

CD47 is a widely distributed cell-surface protein that acts a marker of self through interactions
of myeloid and neural cells. We describe the high-resolution X-ray crystallographic …

Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their
ability to establish lifelong latent infection in neurons. As for all herpesviruses, …

SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease
2019 (COVID-19) pandemic that continues to cause significant global mortality in human …

SNAREs provide a large part of the specificity and energy needed for membrane fusion and,
to do so, must be localized to their correct membranes. Here, we show that the R-SNAREs …

In the 1950s the myxoma virus was released into European rabbit populations in Australia
and Europe, decimating populations and resulting in the rapid evolution of resistance. We …

Ribonuclease H2 is the major nuclear enzyme degrading cellular RNA/DNA hybrids in
eukaryotes and the sole nuclease known to be able to hydrolyze ribonucleotides misincorporated …

The mammalian homotypic fusion and vacuole protein sorting ( HOPS ) complex is comprised
of six subunits: VPS11 , VPS16 , VPS18 , VPS39 , VPS41 and the Sec1/Munc18 ( SM ) …

Vaccinia virus (VACV), the prototype poxvirus, encodes numerous proteins that modulate
the host response to infection. Two such proteins, B14 and A52, act inside infected cells to …