Malaria resulting from Plasmodium falciparum infection is a major cause of human suffering
and mortality. Red blood cell (RBC) deformability plays a major role in the pathogenesis of …

Malaria is a major cause of global morbidity and mortality, and new strategies for treating and
preventing this disease are needed. Here we show that the Streptococcus pyogenes Cas9 …

Synthetic posttranscriptional regulation of gene expression is important for understanding
fundamental biology and programming new cellular processes in synthetic biology. Previous …

Although structural studies of individual T cell receptors (TCRs) have revealed important
roles for both the α and β chain in directing MHC and antigen recognition, repertoire-level …

We have developed a novel multimodal microscopy system that incorporates confocal
Raman, confocal reflectance, and quantitative phase microscopy (QPM) into a single imaging …

We propose that rearrangements between short tandem repeated sequences occur by errors
made during a replication fork repair pathway involving a replication template switch. We …

The available tools for conditional gene expression in Plasmodium falciparum are limited.
Here, to enable reliable control of target gene expression, we build a system to efficiently …

Establishing robust genome engineering methods in the malarial parasite, Plasmodium
falciparum, has the potential to substantially improve the efficiency with which we gain …

Sequence-specific RNA–protein interactions, though commonly used in biological systems
to regulate translation, are challenging to selectively modulate. Here, we demonstrate the …

A diverse T cell repertoire is a critical component of the adaptive immune system, providing
protection against invading pathogens and neoplastic changes, relying on the recognition of …