Optokinetic and phototactic behaviors of zebrafish larvae were examined for their usefulness
in screening for recessive defects in the visual system. The optokinetic response can be …

Calmodulin is a small Ca2+-binding protein proposed to act as the intracellular Ca*+ receptor
that translates Ca*+ signals into cellular responses. We have constructed mutant yeast …

10.7554/eLife.28899.001 Here we report multiple lines of evidence for a comprehensive model
of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and …

Our laboratory screens for visual mutants by examining larval eye movements in response
to rotating illuminated stripes. This behavior, which is termed an optokinetic response (OKR), …

Ciliopathies are a genetically and phenotypically heterogeneous group of human developmental
disorders whose root cause is the absence or dysfunction of primary cilia. Joubert …

Photoreceptor degeneration is a common cause of inherited blindness worldwide. We have
identified a blind zebrafish mutant with rapid degeneration of cone photoreceptors caused …

We describe the effects of a recessive mutation on visual behavior, the electroretinogram (ERG),
and photoreceptor structure in zebrafish. At 6 d post-fertilization (dpf), no optokinetic …

A red-blind zebrafish mutant, partial optokinetic response b (pob), has been isolated by
measuring eye movements of larvae in a three-generation screen for recessive mutations …

Abnormalities in the ability of cells to properly degrade proteins have been identified in
many neurodegenerative diseases. Recent work has implicated synaptojanin 1 (SynJ1) in …

Abstract Development of therapies to treat visual system dystrophies resulting from the
degeneration of rod and cone photoreceptors may directly benefit from studies of animal models, …