Bone sialoprotein (BSP) is an acidic, noncollagenous glycoprotein abundantly expressed in
mineralized tissues. Although BSP is frequently used as a marker of osteoblast …

A key cellular process associated with the invasive or metastatic program in many cancers
is the transformation of epithelial cells toward a mesenchymal state, a process called …

OBJECTIVE—Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis
of diabetes, but the roles of specific ER Ca 2+ release channels in the ER stress–associated …

Dermal fibroblasts exhibit considerable heterogeneity during homeostasis and in response
to injury. Defining lineage origins of reparative fibroblasts and regulatory programs that drive …

Accurate measurement of clonal genotypes, mutational processes, and replication states
from individual tumor-cell genomes will facilitate improved understanding of tumor evolution. …

Ocular mal-development results in heterogeneous and frequently visually disabling
phenotypes that include coloboma and microphthalmia. Due to the contribution of bone …

Many adult tissues contain resident stem cells, such as the Pax7 + satellite cells within
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …

Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal
event generates SS18-SSX fusion transcripts. In vitro and in vivo studies have shown that …

The majority of the vertebrate skeleton develops through the process of endochondral
ossification and involves successive steps of chondrogenesis, chondrocyte proliferation, and …

Chromatin modulators are emerging as attractive drug targets, given their widespread
implication in human cancers and susceptibility to pharmacological inhibition. Here we establish …