Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal
recessive early onset Parkinson’s disease 1 , 2 . PINK1 has many unique features that enable it …

PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key
signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their …

Ubiquitination is a fundamental post-translational modification that regulates almost all aspects
of cellular signalling and is ultimately catalysed by the action of E3 ubiquitin ligases. The …

Myostatin, a key regulator of muscle mass in vertebrates, is biosynthesised as a latent
precursor in muscle and is activated by sequential proteolysis of the pro‐domain. To investigate …

An increasing number of genetic diseases are linked to deregulation of E3 ubiquitin ligases.
Loss-of-function mutations in the RING-between-RING (RBR) family E3 ligase RNF216 (…

Background The community-based participatory research (CBPR)-driven health needs
assessment was a tool used to inform community-led,-implemented, and-sustained research and …

Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8
is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. …

This paper summarizes the historical events from the identification of the Yucca Mountain
site in southern Nevada in 1978 to its selection by the US Congress as the sole site to …

The RING-between-RING (RBR) E3 ubiquitin ligase family in humans comprises 14 members
and is defined by a two-step catalytic mechanism in which ubiquitin is first transferred from …

This article presents the processes associated with a participatory evaluation of alumni
groups—Think Tanks—affiliated with the Inside-Out Prison Exchange Program. The participatory …