User profiles for Thomas M Werge
 | Thomas WergeDirector, Professor, RHP-Institute of Biological Psychiatry & University of Copenhagen Verified email at regionh.dk Cited by 70331 |
Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic
genetic architecture. However, little is known about how genetic variants impart brain …
genetic architecture. However, little is known about how genetic variants impart brain …
Heritability of schizophrenia and schizophrenia spectrum based on the nationwide Danish twin register
… Author links open overlay panel Rikke Hilker a b c 1 , Dorte Helenius d e 1 , Birgitte Fagerlund
a b , Axel Skytthe f , Kaare Christensen f , Thomas M. Werge a d e , Merete Nordentoft a c …
a b , Axel Skytthe f , Kaare Christensen f , Thomas M. Werge a d e , Merete Nordentoft a c …
Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and …
C Galli, O Meucci, A Scorziello, TM Werge… - Journal of …, 1995 - Soc Neuroscience
Cerebellar granule cells deprived of depolarizing concentration of extracellular potassium, [K+]o,
undergo apoptosis. We here report that this apoptotic process is associated with an …
undergo apoptosis. We here report that this apoptotic process is associated with an …
[HTML][HTML] An epigenetic clock for gestational age at birth based on blood methylation data
…, PB Mortensen, SM Weinsheimer, TM Werge… - Genome biology, 2016 - Springer
Background Gestational age is often used as a proxy for developmental maturity by clinicians
and researchers alike. DNA methylation has previously been shown to be associated with …
and researchers alike. DNA methylation has previously been shown to be associated with …
Population genetic differentiation of height and body mass index across Europe
…, LH Berg, JH Veldink, F Rivadeneira, TM Werge… - Nature …, 2015 - nature.com
Across-nation differences in the mean values for complex traits are common 1 , 2 , 3 , 4 , 5 ,
6 , 7 , 8 , but the reasons for these differences are unknown. Here we find that many …
6 , 7 , 8 , but the reasons for these differences are unknown. Here we find that many …
Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants
The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD)
and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, …
and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, …
A mouse model that recapitulates cardinal features of the 15q13. 3 microdeletion syndrome including schizophrenia-and epilepsy-related alterations
…, TM Werge, P Kallunki, KV Christensen, M Didriksen - Biological …, 2014 - Elsevier
Background Genome-wide scans have uncovered rare copy number variants conferring high
risk of psychiatric disorders. The 15q13.3 microdeletion is associated with a considerably …
risk of psychiatric disorders. The 15q13.3 microdeletion is associated with a considerably …
GABAA Receptor Function is Regulated by Lipid Bilayer Elasticity
R Søgaard, TM Werge, C Bertelsen, C Lundbye… - Biochemistry, 2006 - ACS Publications
Docosahexaenoic acid (DHA) and other polyunsaturated fatty acids (PUFAs) promote
GABA A receptor [ 3 H]-muscimol binding, and DHA increases the rate of GABA A receptor …
GABA A receptor [ 3 H]-muscimol binding, and DHA increases the rate of GABA A receptor …
The anorexia nervosa genetics initiative (ANGI): overview and methods
Background Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide
significant locus has been identified. We describe methods and procedures for the Anorexia …
significant locus has been identified. We describe methods and procedures for the Anorexia …