INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n
= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …

Through complementary application of SNP genotyping, whole-genome sequencing and
imputation in 38,384 Icelanders, we have discovered a previously unidentified sick sinus …

Reduced fecundity, associated with severe mental disorders 1 , places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …

Background Twin studies have provided evidence that both genetic and environmental
factors contribute to schizophrenia (SZ) risk. Heritability estimates of SZ in twin samples have …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …