User profiles for Timothy A Blenkinsop
 | Timothy A BlenkinsopIcahn School of Medicine at Mount Sinai Verified email at mssm.edu Cited by 1906 |
[PDF][PDF] Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives
The retinal pigment epithelium (RPE) is a monolayer of cells underlying and supporting the
neural retina. It begins as a plastic tissue, capable, in some species, of generating lens and …
neural retina. It begins as a plastic tissue, capable, in some species, of generating lens and …
[PDF][PDF] Human RPE stem cells grown into polarized RPE monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space
Transplantation of the retinal pigment epithelium (RPE) is being developed as a cell-replacement
therapy for age-related macular degeneration. Human embryonic stem cell (hESC) …
therapy for age-related macular degeneration. Human embryonic stem cell (hESC) …
[PDF][PDF] Nicotinamide ameliorates disease phenotypes in a human iPSC model of age-related macular degeneration
Age-related macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell
monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the …
monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the …
The culture and maintenance of functional retinal pigment epithelial monolayers from adult human eye
TA Blenkinsop, E Salero, JH Stern… - Epithelial Cell Culture …, 2013 - Springer
The retinal pigment epithelium (RPE) is implicated in many eye diseases, including age-related
macular degeneration, and therefore isolating and culturing these cells from recently …
macular degeneration, and therefore isolating and culturing these cells from recently …
Block of inferior olive gap junctional coupling decreases Purkinje cell complex spike synchrony and rhythmicity
TA Blenkinsop, EJ Lang - Journal of Neuroscience, 2006 - Soc Neuroscience
Inferior olivary (IO) neurons are electrotonically coupled by gap junctions. This coupling is
thought to underlie synchronous complex spike (CS) activity generated by the olivocerebellar …
thought to underlie synchronous complex spike (CS) activity generated by the olivocerebellar …
[PDF][PDF] SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium
The SARS-CoV-2 pandemic has caused unparalleled disruption of global behavior and
significant loss of life. To minimize SARS-CoV-2 spread, understanding the mechanisms of …
significant loss of life. To minimize SARS-CoV-2 spread, understanding the mechanisms of …
[HTML][HTML] Human adult retinal pigment epithelial stem cell–derived RPE monolayers exhibit key physiological characteristics of native tissue
TA Blenkinsop, JS Saini, A Maminishkis… - … & visual science, 2015 - iovs.arvojournals.org
Purpose: We tested what native features have been preserved with a new culture protocol
for adult human RPE. Methods: We cultured RPE from adult human eyes. Standard protocols …
for adult human RPE. Methods: We cultured RPE from adult human eyes. Standard protocols …
[HTML][HTML] SARS-CoV-2 infection of ocular cells from human adult donor eyes and hESC-derived eye organoids
The outbreak of COVID-19 caused by the SARS-CoV-2 virus has created an unparalleled
disruption of global behavior and a significant loss of human lives. To minimize SARS-CoV-2 …
disruption of global behavior and a significant loss of human lives. To minimize SARS-CoV-2 …
[PDF][PDF] Surgical transplantation of human RPE stem cell-derived RPE monolayers into non-human primates with immunosuppression
Recent trials of retinal pigment epithelium (RPE) transplantation for the treatment of disorders
such as age-related macular degeneration have been promising. However, limitations of …
such as age-related macular degeneration have been promising. However, limitations of …
Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration
…, M Fernandes, TA Blenkinsop… - Proceedings of the …, 2018 - National Acad Sciences
Abnormally enlarged early endosomes (EEs) are pathological features of neurodegenerative
diseases, yet insight into the mechanisms and consequences of EE expansion remains …
diseases, yet insight into the mechanisms and consequences of EE expansion remains …