Precision medicine promises to transform healthcare for groups and individuals through
early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale …

T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for
cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the …

Since 2020, synchrotron radiation facilities in several Asia-Pacific countries have been
collaborating in a major project called “SYNAPSE” (Synchrotrons for Neuroscience: an Asia-…

Antimicrobial peptides (AMPs) are important components of the innate immune system of
many species. These peptides are found in eukaryotes, including mammals, amphibians, …

Background Influenza A viruses generate an extreme genetic diversity through point mutation
and gene segment exchange, resulting in many new strains that emerge from the animal …

Background The identification of mutations that confer unique properties to a pathogen,
such as host range, is of fundamental importance in the fight against disease. This paper …

Background Genetic variation and rapid evolution are hallmarks of RNA viruses, the result
of high mutation rates in RNA replication and selection of mutants that enhance viral …

Epitope-based vaccines provide a new strategy for prophylactic and therapeutic application
of pathogen-specific immunity. A critical requirement of this strategy is the identification and …

Background The signal peptide plays an important role in protein targeting and protein
translocation in both prokaryotic and eukaryotic cells. This transient, short peptide sequence …

With the increasing need for bioinformatics expertise in the life sciences, a coordinated effort
is needed to proactively and critically reflect on the challenges of educating and training life …