Background Glucocorticoids (GCs) are commonly used for long-term medication in
immunosuppressive and anti-inflammatory therapy. However, the data describing gluco- and …

Objective Severe hyponatremia due to hypopituitarism and adrenal insufficiency can be life-threatening,
and treatment with glucocorticoids is very effective once the diagnosis of the …

Tetracosactin [corticotropin-(1–24)] is used for clinical testing of adrenocortical responsiveness.
The usual dose [high dose test (HDT)] is 250 μg. With this test, patients with mild …

The 11β-hydroxysteroid dehydrogenase (11β-HSD) system plays a pivotal role in glucocorticoid
(GC) and mineralocorticoid (MC) action. Although 11β-HSD activities are important …

Torsemide inhibited aldosterone secretion by adrenal cells from rats, cows, and guinea pigs
stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. …

The flavones apigenin (4′,5,7,-trihydroxyflavone) and luteolin (3′,4′,5,7,-tetrahydroxyflavone)
are plant secondary metabolites with antioxidant, antiinflammatory, and anticancer …

Context and Objective: Inactivating mutations in the calcium-sensing receptor (CaSR) gene
cause neonatal severe hyperparathyroidism and familial hypocalciuric hypercalcemia (FHH). …

Progesterone binds with high affinity to the mineralocorticoid (MC) receptor, but confers only
very low agonistic MC activity. Therefore, progesterone is a potent MC antagonist in vitro. …

Objective Glucocorticoids exert tonic suppression of antidiuretic hormone (ADH) secretion.
Hypocortisolism in secondary adrenocortical insufficiency can result in a clinical picture …

The presence of an 11β-hydroxyl group is essential for the anti-inflammatory and
immunosuppressive effects of glucocorticoids. Interconversion of the 11β-hydroxyl into the …