Background Measurement of genome-wide DNA methylation (DNAm) has become an important
avenue for investigating potential physiologically-relevant epigenetic changes. Illumina …

Uniparental disomy (UPD) refers to the situation in which both copies of a chromosome pair
have originated from one parent. In humans, it can result in clinical conditions by producing …

Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but
also over larger genomic regions. In most human tissues, the vast majority of the genome is …

From 11 studies, a total of 1,792 Caucasian probands with insulin-dependent diabetes
mellitus (IDDM) are analyzed. Antigen genotype frequencies in patients, transmission from …

OBJECTIVE: Female fertility declines with age; however, women are increasingly delaying
childbearing until later in their reproductive years. One of the factors that may contribute to …

Maternal uniparental disomy for the entire chromosome 7 has so far been reported in three
patients with intrauterine and postnatal growth retardation. Two were detected because they …

Preeclampsia and intrauterine growth restriction (IUGR) are two of the most common adverse
pregnancy outcomes, but their underlying causes are mostly unknown. Although multiple …

Pre-eclampsia is a serious complication of pregnancy that can affect both maternal and fetal
outcomes. Early-onset pre-eclampsia (EOPET) is a severe form of pre-eclampsia that is …

Premature ovarian failure (POF) is the occurrence of menopause before the age of 40 and
affects 1% of the female population. Whereas the etiology of POF is largely unexplained, …

Background The human placenta facilitates the exchange of nutrients, gas and waste between
the fetal and maternal circulations. It also protects the fetus from the maternal immune …