Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP) maps
will produce data sets that exceed the limitations of current computational tools. Here we …

Background The study of microbial communities has been revolutionised in recent years by
the widespread adoption of culture independent analytical techniques such as 16S rRNA …

Family studies of IgE responses to common inhaled antigens have suggested dominant
inheritance of atopy. Molecular genetic linkage analysis was used to confirm this proposal. In …

Approaches exploiting trait distribution extremes may be used to identify loci associated
with common traits, but it is unknown whether these loci are generalizable to the broader …

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease.
We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …

Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress
in the molecular dissection of complex traits in mice. Here we show that genome-wide high-…

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …

The composition of the lung microbiome contributes to both health and disease, including
obstructive lung disease. Because it has been estimated that over 70% of the bacterial species …

The interaction between genotype and environment is recognized as an important source of
experimental variation when complex traits are measured in the mouse, but the magnitude …

Background Patients with asthma and healthy controls differ in bacterial colonization of the
respiratory tract. The upper airways have been shown to reflect colonization of the lower …