A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development 1 , 2 , 3 , 4 , 5 . However, its dynamic patterns have not been analysed at the …

The mammalian prefrontal cortex comprises a set of highly specialized brain areas containing
billions of cells and serves as the centre of the highest-order cognitive functions, such as …

Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for maintenance
of the species. However, the developmental trajectories and heterogeneity of human …

Circular RNAs (circRNAs) are a new class of non-polyadenylated non-coding RNAs that may
play important roles in many biological processes. Here we develop a single-cell universal …

The heart is the central organ of the circulatory system, and its proper development is vital
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …

Spermatogenesis generates mature male gametes and is critical for the proper transmission
of genetic information between generations. However, the developmental landscapes of …

Diffuse malignant gliomas, the most common type of brain tumor, carry a dire prognosis and
are poorly responsive to initial treatment. The response to treatment is typically evaluated by …

The placenta is crucial for a successful pregnancy and the health of both the fetus and the
pregnant woman. However, how the human trophoblast lineage is regulated, including the …

Spermatogonial stem cells (SSCs) can produce numerous male gametes after transplantation
into recipient testes, presenting a valuable approach for gene therapy and continuous …