Mechanisms of metabolic flexibility enable cells to survive under stressful conditions and
can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays central roles in energy …

Objective— Hyperlipidemia-induced endothelial cell (EC) activation is considered as an initial
event responsible for monocyte recruitment in atherogenesis. However, it remains poorly …

We propose a novel application of secondary electrospray ionization-mass spectrometry (SESI-MS)
as a real-time clinical diagnostic tool for bacterial infection. It is known that volatile …

Although p300 and CBP lysine acetyltransferases are often treated interchangeably, the
inability of one enzyme to compensate for the loss of the other suggests unique roles for each. …

Cellular metabolism dynamically regulates the epigenome via availability of the metabolite
substrates of chromatin-modifying enzymes. The impact of diet on the metabolism-…

Lysine acetyltransferases (KATs) play a unique role in regulating gene transcription as well
as maintaining the epigenetic state of the cell. KATs such as Gcn5 and p300/CBP can modify …

Objective— IL-35 (interleukin-35) is an anti-inflammatory cytokine, which inhibits immune
responses by inducing regulatory T cells and regulatory B cells and suppressing effector T …

Determining how histone acetylation is regulated is vital for treating the many diseases
associated with its misregulation, including heart disease, neurological disorders, and cancer. …

Several metabolic enzymes undergo reversible polymerization into macromolecular
assemblies. The function of these assemblies is often unclear, but in some cases they regulate …

T cell-mediated adaptive immunity requires naïve, unstimulated T cells to transition from a
quiescent metabolic state into a highly proliferative state upon T cell receptor engagement. …