The molecular mechanisms underlying major phenotypic changes that have evolved
repeatedly in nature are generally unknown. Pelvic loss in different natural populations of …

Marine stickleback fish have colonized and adapted to thousands of streams and lakes
formed since the last ice age, providing an exceptional opportunity to characterize genomic …

Genetic variation segregates as linked sets of variants or haplotypes. Haplotypes and
linkage are central to genetics and underpin virtually all genetic and selection analysis. Yet, …

Ecological differences often evolve early in speciation as divergent natural selection drives
adaptation to distinct ecological niches, leading ultimately to reproductive isolation. Although …

Genes underlying repeated adaptive evolution in natural populations are still largely unknown.
Stickleback fish (Gasterosteus aculeatus) have undergone a recent dramatic evolutionary …

Repeated evolution can provide insight into the mechanisms that facilitate adaptation to novel
or changing environments. Here we study adaptation to altitude in two tropical butterflies, …

Understanding how polygenic traits evolve under selection is an unsolved problem [1], because
challenges exist for identifying genes underlying a complex trait and understanding how …

10.7554/eLife.38555.001 Vertebrate pelvic reduction is a classic example of repeated
evolution. Recurrent loss of pelvic appendages in sticklebacks has previously been linked to …

Inexpensive genotyping methods are essential to modern genomics. Here we present QUILT,
which performs diploid genotype imputation using low-coverage whole-genome sequence …

Complete genome sequencing has identified millions of DNA changes that differ between
humans and chimpanzees. Although a subset of these changes likely underlies important …