Each person’s genome sequence has thousands of missense variants. Practical interpretation
of their functional significance must rely on computational inferences in the absence of …

Liver-resident CD8 + T cells are highly motile cells that patrol the vasculature and provide
protection against liver pathogens. A key question is: How can these liver CD8 + T cells be …

IgD and IgM are produced by alternative splicing of long primary RNA transcripts from the Ig
heavy chain (Igh) locus and serve as the receptors for antigen on naïve mature B …

Notch signalling is critical to help direct T‐cell lineage commitment in early T‐cell progenitors
and in the development of αβ T‐cells. Epithelial and stromal cell populations in the thymus …

Hematopoietic stem cells (HSCs) are rare, ancestral cells that underlie the development,
homeostasis, aging, and regeneration of the blood. Here we show that the chromatin-…

The molecular mechanisms tuning cholinergic interneuron (CIN) activity, although crucial
for striatal function and behavior, remain largely unexplored. Previous studies report that the …

Special AT‐binding protein 1 (SATB1) is a chromatin‐binding protein that has been shown to
be a key regulator of T‐cell development and CD4 + T‐cell fate decisions and function. The …

T-cell immunity requires extremely rapid clonal proliferation of rare, antigen-specific T
lymphocytes to form effector cells. Here we identify a critical role for ETAA1 in this process by …

DOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and
function. Patients with this immunodeficiency have a high morbidity and mortality, and are …

A rising concern in Autism Spectrum Disorder (ASD) is the heightened sensitivity to trauma,
the potential consequences of which have been overlooked, particularly upon the severity of …