The past 25 years have seen a major expansion of knowledge concerning the cause of
Parkinson's disease provided by an understanding of environmental and genetic factors that …

Following the discovery of a higher than expected incidence of Parkinson Disease (PD) in
Gaucher disease, a lysosomal storage disorder, mutations in the glucocerebrocidase (GBA) …

The initial association between the development of valvular heart disease and drugs stems
from observations made during the use of methysergide and ergotamine for migraine …

Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct
transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons …

… Schapira: drafting/revising the manuscript for content, including medical writing for
content; study concept or design; analysis or interpretation of data; study supervision or …

A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for
study. One solution is to derive induced pluripotent stem cells from patients and differentiate …

The Stalevo Reduction in Dyskinesia Evaluation in Parkinson's Disease ( STRIDE‐PD ) study
compared the initiation of levodopa (l‐dopa) therapy with l‐dopa/carbidopa ( LC ) versus l‐…

Mutations of the gene for glucocerebrosidase 1 (GBA) cause Gaucher disease (GD), an
autosomal recessive lysosomal storage disorder. Individuals with homozygous or heterozygous (…

Accumulating evidence implicates acidic organelles of the endolysosomal system as mobilisable
stores of Ca 2+ but their relationship to the better-characterised endoplasmic reticulum (…

Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca 2+ signalling
from acidic organelles. The relevance of these ubiquitous proteins for human disease, …