Replication protein A unfolds G-quadruplex structures with varying degrees of efficiency

MH Qureshi, S Ray, AL Sewell, S Basu… - The Journal of Physical …, 2012 - ACS Publications
Replication protein A (RPA) is known to interact with guanine- (G-) rich sequences that adopt
G-quadruplex (GQ) structures. Most studies reported in the literature were performed on …

[HTML][HTML] Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

ET Tjhin, C Spry, AL Sewell, A Hoegl, L Barnard… - PLoS …, 2018 - journals.plos.org
The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate
for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five …

[HTML][HTML] Tunable BODIPY derivatives amenable to 'click'and peptide chemistry

AM Hansen, AL Sewell, RH Pedersen, DL Long… - Tetrahedron, 2013 - Elsevier
Novel azido- and amino-functionalised fluorescent probes based on the BODIPY framework
have been developed. The probes can be easily and cheaply synthesised, exhibit the highly …

[HTML][HTML] Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity

…, C Alfonso Martin, J Zhang, AL Sewell… - Journal of …, 2022 - Springer
Encephalopathy of prematurity (EoP) affects approximately 30% of infants born < 32 weeks
gestation and is highly associated with inflammation in the foetus. Here we evaluated the …

Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans

…, E Hultman, IA Macdonald, DA Sewell… - American Journal …, 1996 - journals.physiology.org
This study investigated the effect of carbohydrate (CHO) ingestion on skeletal muscle
creatine (Cr) accumulation during Cr supplementation in humans. Muscle biopsy, urine, and …

Fast and flexible synthesis of pantothenic acid and CJ-15,801

AL Sewell, MVJ Villa, M Matheson… - Organic …, 2011 - ACS Publications
Sewell - WestCHEM, University of Glasgow, Joseph Black Building, University Avenue,
Glasgow G12 8QQ, United Kingdom, and Syngenta, Jealott’s Hill Research Centre …

Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation

C Spry, AL Sewell, Y Hering, MVJ Villa, J Weber… - European Journal of …, 2018 - Elsevier
Survival of the human malaria parasite Plasmodium falciparum is dependent on pantothenate
(vitamin B 5 ), a precursor of the fundamental enzyme cofactor coenzyme A. CJ-15,801, an …

Fast, Economic, and Green Synthesis of N-Formylated Benzotriazoles

AE Pasqua, M Matheson, AL Sewell… - … Process Research & …, 2011 - ACS Publications
Formylation is an integral part of organic, medicinal, and biological chemistry both in industrial
and academic set-ups. A reflection of this importance is the number of approaches and …

[BOOK][B] " The Great Calamity!": Scenes, Incidents and Lessons of the Great Chicago Fire of the 8th and 9th of October, 1871. Also Some Account of Other Great …

AL Sewell - 1871 - books.google.com
IN N the preparation of these pages I have received valuable assistance from editors and
others of my personal friends in Chicago. In addition to any pecuniary return I have been …

[BOOK][B] Quantum theory of collective phenomena

GL Sewell - 2014 - books.google.com
… Once this has been achieved, there is no difficulty in extending the model to the
unbounded local observablequ We shall now sketch how this has been done (Sewell 1970). …