Chemical modifications to DNA and histone proteins form a complex regulatory network that
modulates chromatin structure and genome function. The epigenome refers to the complete …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

Epigenome-wide association studies (EWAS) hold promise for the detection of new regulatory
mechanisms that may be susceptible to modification by environmental and lifestyle factors …

The reference human genome sequence set the stage for studies of genetic variation and
its association with human disease, but epigenomic studies lack a similar reference. To …

We report the application of single-molecule-based sequencing technology for high-throughput
profiling of histone modifications in mammalian cells. By obtaining over four billion bases …

DNA methylation is essential for normal development 1 , 2 , 3 and has been implicated in
many pathologies including cancer 4 , 5 . Our knowledge about the genome-wide distribution …

Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency
of iPSC derivation and the fact that most protocols modify the genome to effect cellular …

The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of
epigenomic maps for stem cells and primary ex vivo tissues selected to represent the normal …

miR-17∼92, miR-106b∼25, and miR-106a∼363 belong to a family of highly conserved
miRNA clusters. Amplification and overexpression of miR-17∼92 is observed in human cancers…

Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified
in mammals, few have been functionally characterized, leading to debate about their …