DNA-encoded library (DEL) screening and quantitative structure–activity relationship (QSAR)
modeling are two techniques used in drug discovery to find novel small molecules that …

The ancient UbiB protein kinase-like family is involved in isoprenoid lipid biosynthesis and
is implicated in human diseases, but demonstration of UbiB kinase activity has remained …

The UbiB protein kinase-like (PKL) family is widespread, comprising one-quarter of microbial
PKLs and five human homologs, yet its biochemical activities remain obscure. COQ8A (…

Prion disease is a fatal, incurable neurodegenerative disease of humans and other mammals
caused by conversion of cellular prion protein (PrP C) into a self-propagating neurotoxic …

We report the first high-resolution structural data for the β/γ-peptide 13-helix (i,i+3 CO···HN
H-bonds), a secondary structure that is formed by oligomers with a 1:1 alternation of β- and …

Human COQ8A (ADCK3) and Saccharomyces cerevisiae Coq8p (collectively COQ8) are UbiB
family proteins essential for mitochondrial coenzyme Q (CoQ) biosynthesis. However, the …

The single-conformation spectroscopy of two model γ-peptides has been studied under jet-cooled
conditions in the gas phase. The methyl-capped triamides, Ac-γ 2 -hPhe-γ 2 -hAla-…

The complexity of structure and function among biopolymers has inspired chemists to
extrapolate to non-natural analogues that are intended to emulate the natural archetypes.[1] b-…

Mitoproteases are becoming recognized as key regulators of diverse mitochondrial functions,
although their direct substrates are often difficult to discern. Through multi-omic profiling of …

Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically
and pharmacologically validated therapeutic target for prion disease. In order to evaluate …