Type XVIII collagen is a homotrimeric basement membrane molecule of unknown function,
whose COOH-terminal NC1 domain contains endostatin (ES), a potent antiangiogenic agent. …

Papilin is an extracellular matrix glycoprotein that we have found to be involved in, (1) thin
matrix layers during gastrulation, (2) matrix associated with wandering, phagocytic hemocytes, …

Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding
protein implicated in the modulation of both constitutive and regulated exocytosis. To …

… I thank members of the Ackley lab for their critical reading of this manuscript. I regret
being unable to cover the contributions of some of my colleagues due to space restrictions. …

C. elegans RPM-1 (for Regulator of Presynaptic Morphology) is a member of a conserved
protein family that includes Drosophila Highwire and mammalian Pam and Phr1. These are …

… (Kim and Wadsworth, 2000; Ackley et al., 2003). Likewise, mutations in Eph signaling cause
synaptic defects that are distinct from those in ptp-3 (BD Ackley and Y. Jin, unpublished data)…

Vertebrate neuromuscular junctions (NMJs) contain specialized basal laminas enriched for
proteins not found at high concentrations extrasynaptically. Alterations in NMJ basement …

Mitochondria undergo dynamic fusion and fission events that affect the structure and function
of these critical energy-producing cellular organelles. Defects in these dynamic processes …

Development of a functional neuronal network during embryogenesis begins with pioneer
axons creating a scaffold along which later-outgrowing axons extend. The molecular …

Collagen XVIII (c18) is a triple helical endothelial/epithelial basement membrane protein
whose noncollagenous (NC)1 region trimerizes a COOH-terminal endostatin (ES) domain …