User profiles for B. Ueberheide

Beatrix Ueberheide

New York University, School of Medicine
Verified email at nyumc.org
Cited by 13561

The utility of ETD mass spectrometry in proteomic analysis

LM Mikesh, B Ueberheide, A Chi, JJ Coon… - … et Biophysica Acta (BBA …, 2006 - Elsevier
… The rest of the CAD spectrum is composed of a total of three b and y-type ions (b 6 +2 , b
14 +2 , and y 10 +2 ), none of which are more than 20% of the abundance of the (M+3H-GlcNAc…

Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding

JF Scheid, H Mouquet, B Ueberheide, R Diskin, F Klein… - Science, 2011 - science.org
… From single sorted B cells representing 200 different B cell clones that were diversified by
mutation in germinal centers, 576 antibodies were obtained from a starting population of 1.5 × …

Regulation of HP1–chromatin binding by histone H3 methylation and phosphorylation

W Fischle, BS Tseng, HL Dormann, BM Ueberheide… - Nature, 2005 - nature.com
… is caused by phosphorylation of H3S10 by Aurora B, we monitored the chromosome-binding
activity of xHP1 in egg extracts depleted of the Aurora B-containing CPC complex (ΔCPC) …

Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery

…, EAB Undheim, B Ueberheide… - Expert review of …, 2017 - Taylor & Francis
… (b) Toxin-driven discovery of venom peptides requires small amounts of both venom-producing
tissue and venom, which are used to generate a transcriptome and venom peptidome, …

[HTML][HTML] Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

JC Rice, SD Briggs, B Ueberheide, CM Barber… - Molecular cell, 2003 - cell.com
The functional significance of mono-, di-, and trimethylation of lysine residues within histone
proteins remains unclear. Antibodies developed to selectively recognize each of these …

Protein identification using sequential ion/ion reactions and tandem mass spectrometry

JJ Coon, B Ueberheide, JEP Syka… - Proceedings of the …, 2005 - National Acad Sciences
… of 0–60% B for 12 min and 60–100% B for 2 min (A = 0.1 M formic acid, B = 70% acetonitrile
in … a linear gradient of 0–5% B for 15 min and 5–100% B for 15 min (A = 0.1 M acetic acid, …

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

…, CB Lock, LB Kipp, VC Cotham, BM Ueberheide… - Nature, 2022 - nature.com
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …

Novel linear quadrupole ion trap/FT mass spectrometer: performance characterization and use in the comparative analysis of histone H3 post-translational …

…, JC Schwartz, B Ueberheide, B Garcia… - Journal of proteome …, 2004 - ACS Publications
… gradient of 0−60% B in 120 min and 60−100% B in 10 min (A … We conclude that the spectra
in Figure 5, parts A and B, … , singly charged fragment ions corresponding to b 6 , b 7 , and y 5 …

Chemical derivatization of histones for facilitated analysis by mass spectrometry

BA Garcia, S Mollah, BM Ueberheide, SA Busby… - Nature protocols, 2007 - nature.com
Histone post-translational modifications have been recently intensely studied owing to their
role in regulating gene expression. Here, we describe protocols for the characterization of …

[PDF][PDF] Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1

…, HI Pass, AJ Bhutkar, A Tsirigos, B Ueberheide… - Cell, 2019 - cell.com
… than KP-shCtrl cells (Figure 6B). Ho1 inhibition by ZnPPIX treatment significantly reduced
metastasis in both KP and KPK models (Figure 6B) without having any significant impact on …