… Financial Disclosures: Dr Blau reported that he was named as an inventor on patent
applications related to the regulation of blood cell production and is a cofounder of CellNexus LLC, …

… Anthony Blau … Anthony Blau … Studies involving transduction with drug resistance
genes, genes allowing selective proliferation and amplification of cells, or the homeobox …

Accumulating evidence demonstrates that the three-dimensional (3D) organization of
chromosomes within the eukaryotic nucleus reflects and influences genomic activities, including …

Layered on top of information conveyed by DNA sequence and chromatin are higher order
structures that encompass portions of chromosomes, entire chromosomes, and even whole …

The function of metabolic state in stemness is poorly understood. Mouse embryonicstem
cells (ESC) and epiblast stem cells (EpiSC) are at distinct pluripotent statesrepresenting the …

Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors,
hypoxia is associated with aggressive disease course and poor clinical outcomes. …

The naïve pluripotent state has been shown in mice to lead to broad and more robust
developmental potential relative to primed mouse epiblast cells. The human naïve ES cell state …

For nearly a century developmental biologists have recognized that cells from embryos can
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …

Despite progress in developing defined conditions for human embryonic stem cell (hESC)
cultures, little is known about the cell-surface receptors that are activated under conditions …

Cancers that appear pathologically similar often respond differently to the same drug
regimens. Methods to better match patients to drugs are in high demand. We demonstrate a …